Arsenal joined Manchester United and Liverpool on the FA Cup scrapheap on Sunday when Ricardo Fuller's double helped Stoke City to a 3-1 fourth round victory at the Britannia Stadium.
FA Cup holders Chelsea booked their place in the fifth round with a comfortable 2-0 victory over Championship (second division) side Preston North End on Saturday.
Bookies have placed Premier League leaders Chelsea as the new clear favourites with 3-1 odds to retain the FA Cup following Sunday's fourth-round draw.
Bert Trautmann, a former German Prisoner of War who became a footballer in England and famously broke his neck playing in goal for Manchester City in the 1956 FA Cup final, died on Friday at the age of 89.
The Merseysiders fell behind to a Raul Jimenez goal on the break in the 38th minute, the Mexican firing home confidently after Diogo Jota robbed James Milner.
It might not save manager Antonio Conte's job but Chelsea can still salvage a disappointing season by winning Saturday's FA Cup final
Arsenal's defence of the trophy ended with something of a whimper as Mikel Arteta's side struggled with repeatedly sloppy defending.
Two goals for Roman Pavlyuchenko and two own goals helped Tottenham Hotspur advance to an FA Cup quarter-final meeting with Fulham after a 4-0 home win over Bolton Wanderers in their fifth-round replay on Wednesday.
Arsenal recovered from going two goals down in the opening eight minutes to beat Hull City 3-2 after extra time in the FA Cup final and win their first trophy for nine years at Wembley on Saturday.
Arsenal striker Lukas Podolski scored twice in the opening half-hour as the Premier League leaders romped to a 4-0 win over third-tier Coventry City in their FA Cup fourth round tie at the Emirates on Friday.
Nicolas Anelka rescued Chelsea's FA Cup hopes on Saturday, scoring a hat-trick in a 3-1 victory at Watford to avoid a shock fifth-round exit. In their first game since Luiz Felipe Scolari was sacked and with replacement manager Guus Hiddink watching in the stands, Chelsea fell behind to the Championship (second division) strugglers when Tamas Priskin netted with 21 minutes remaining.
English third-tier club Sheffield United kept alive their FA Cup dream on Sunday when two goals in as many minutes gave them a 2-0 victory over Charlton Athletic and a place in the semi-finals.
West Ham United's record buy Dean Ashton scored twice in a 2-1 win at Manchester City
Liverpool have not beaten Manchester United in the FA Cup for 85 years
Manchester United reached the FA Cup fifth round and avoided any further embarrassment.
Holders Chelsea eased into the FA Cup quarter-finals with a 4-1 home victory over Championship (second division) side Cardiff City on Saturday while Portsmouth won by the same score at local rivals Southampton. After a season of shocks, the upsets dried up in the fifth round as Birmingham City came from behind to win 2-1 at Championship side Derby County with a last-minute goal by Liam Ridgewell while Manchester City and Stoke City drew 1-1.
Holders Chelsea and Premier League champions Manchester United were bundled out of the FA Cup quarter-finals. Chelsea lost 1-0 at Championship (second division) side Barnsley, while Portsmouth won 1-0 at Old Trafford.
Manchester City reached the FA Cup final for the first time since 1981 after a dramatic 1-0 win over arch rivals Manchester United, who finished with 10 men after midfielder Paul Scholes was sent off 18 minutes from time.
Jack Wilshere's late strike gave Arsenal a 1-0 FA Cup third-round replay win over Swansea City and Wayne Rooney's first goal in over a month earned Manchester United a 1-0 victory over West Ham United on Wednesday.
Middlesbrough were rewarded for beating Manchester City with a trip to FA Cup holders Arsenal while Chelsea's conquerors Bradford City host Sunderland or Fulham after the fifth round draw on Monday.
Fourth-tier Newport County stunned former FA Cup winners Leeds United with a last-gasp 2-1 win in the third round to spark a joyous pitch invasion at their Rodney Parade ground on Sunday.
Portsmouth beat Cardiff City 1-0 to win their first FA Cup since 1939.
Favourites Chelsea will play Tottenham Hotspur in the FA Cup quarter-final tie at Stamford Bridge next month.
Leaders Manchester United will meet Premier League rivals Reading in the FA Cup fifth round.
Much-maligned striker Fernando Torres rescued FA Cup holders Chelsea from an ignominious fourth-round exit after his 83rd-minute equaliser salvaged a 2-2 draw at third tier Brentford on Sunday.
A hat-trick by Jermain Defoe sent Tottenham Hotspur into the fifth round of the FA Cup on Wednesday as the Premier League side beat League One Leeds 3-1 away in a pulsating fourth-round replay. Leeds, going well in the third tier of English football, had knocked out Manchester United at Old Trafford in the previous round and snatched a 2-2 White Hart Lane draw in the original game.
Chelsea beat Tottenham Hotspur 2-1 and league leaders Manchester United overcame Middlesbrough 1-0.
Didier Drogba struck late to clinch a 2-1 victory for Chelsea over Arsenal in the FA Cup semi-final at Wembley on Saturday. The Ivory Coast striker pounced on Frank Lampard's lofted pass with six minutes remaining to give Chelsea their first FA Cup success over Arsenal since 1947.
Jose Mourinho got the perfect birthday present when his Chelsea side beat Stoke City 1-0 in the FA Cup fourth round at Stamford Bridge on Sunday, Brazilian midfielder Oscar scoring the goal from a stunning free kick.
Eleven people were arrested in the Millwall supporters' section of Wembley Stadium on Saturday and four police officers suffered minor injuries after violence marred the London club's FA Cup semi-final defeat by Wigan Athletic.
Michael Owen and Javier Hernandez scored second-half goals as Manchester United fought back to beat League One (third division) Southampton 2-1 in their FA Cup fourth-round tie at St Mary's on Saturday.
Manchester United beat Watford 4-1 to reach their 18th FA Cup final.
Tottenham Hotspur to a 4-0 win at Fulham while Manchester City beat Preston 3-1 to reach the FA Cup quarter-finals.
The Arsenal striker was ruled out of the FA Cup final against Manchester United after a recurrence of a long-standing Achilles problem.
A late strike by Marlon Harewood gave West Ham United a 1-0 victory over Middlesbrough in the semi-final
Striker Georgios Samaras scored his fourth goal in eight games for his new club to give them a 2-1 victory over Aston Villa.
Premier League Swansea City fell victims to the first major giant-killing of the FA Cup third round on Sunday when they lost 3-2 away to League Two (fourth tier) side Oxford United.
Leeds United were handed a tough FA Cup fourth round tie away to Tottenham Hotspur after Sunday's momentous victory over Manchester United at Old Trafford. Leeds, the League One (third division) leaders, scored the biggest Cup upset for years when they beat United 1-0.